InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LILRB2

Summary

InnateDB Protein

IDBP-68449.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LILRB2

Protein Name

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

Synonyms

CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10; MIR10;

Species

Homo sapiens

Ensembl Protein

ENSP00000319960

InnateDB Gene

IDBG-68447 (LILRB2)

Protein Structure

UniProt Annotation

Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269PubMed:11875462, ECO:0000269PubMed:12853576, ECO:0000269PubMed:9548455, ECO:0000269PubMed:9842885}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. {ECO:0000269PubMed:9548455, ECO:0000269PubMed:9842885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008157	protein phosphatase 1 binding
GO:0023029	MHC class Ib protein binding
GO:0032396	inhibitory MHC class I receptor activity
GO:0042288	MHC class I protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002578	negative regulation of antigen processing and presentation
GO:0002666	positive regulation of T cell tolerance induction
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway
GO:0002774	Fc receptor mediated inhibitory signaling pathway
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0032755	positive regulation of interleukin-6 production
GO:0034113	heterotypic cell-cell adhesion
GO:0042102	positive regulation of T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0045591	positive regulation of regulatory T cell differentiation
GO:0050776	regulation of immune response
GO:0051926	negative regulation of calcium ion transport
GO:0071222	cellular response to lipopolysaccharide
GO:2001198	regulation of dendritic cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane