Version 5.4
Homo sapiens Gene: TSN
Summary
InnateDB Gene IDBG-68565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSN
Gene Name translin
Synonyms BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN
Species Homo sapiens
Ensembl Gene ENSG00000211460
Encoded Proteins
IDBP-68567
translin
IDBP-294419
translin
IDBP-385395
translin
IDBP-584100
translin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:121737103-121767853
Strand Forward strand
Band q14.3
Transcripts
ENST00000389682 ENSP00000374332
ENST00000409193 ENSP00000387263
ENST00000455432 ENSP00000399735
ENST00000467324
ENST00000498545
ENST00000483698
ENST00000490717
ENST00000478165
ENST00000490104
ENST00000495112
ENST00000481818
ENST00000536142 ENSP00000437728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006310 DNA recombination
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026374
View Gene Order
ENSBTAG00000006059
Not yet available
Pathways
NETPATH
REACTOME
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75066
RefSeq NM_001261401 NM_004622
HUGO
OMIM
CCDS CCDS33284 CCDS58723
HPRD 08993
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca