InnateDB Protein
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IDBP-68567.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TSN
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Protein Name
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translin
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Synonyms
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BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000374332
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InnateDB Gene
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IDBG-68565 (TSN)
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Protein Structure
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Function |
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11801738}. Nucleus {ECO:0000269PubMed:11801738}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002848
Translin
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PFAM |
PF01997
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15631
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PhosphoSite |
PhosphoSite-Q15631
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7247
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UniGene |
Hs.75066
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RefSeq |
NP_004613
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HUGO |
HGNC:12379
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OMIM |
600575
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CCDS |
CCDS33284
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HPRD |
08993
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IMGT |
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EMBL |
AC018737
AK296469
BC002359
BT019490
BT019491
X78627
Y12563
Y12564
Y12565
Y12566
Y12567
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GenPept |
AAH02359
AAV38297
AAV38298
AAY14831
BAH12364
CAA55341
CAA73150
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