Version 5.4
| Homo sapiens Gene: LAIR1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-68573.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | LAIR1 | ||||||||||||||||||
| Gene Name | leukocyte-associated immunoglobulin-like receptor 1 | ||||||||||||||||||
| Synonyms | CD305; LAIR-1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000167613 | ||||||||||||||||||
| Encoded Proteins |
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
leukocyte-associated immunoglobulin-like receptor 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
LAIR1 play an inhibition role in the mechanisms controlling IFNA production by pDCs both in normal and pathological innate immune responses.
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| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq, Jul 2008] The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:54351384-54370558 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.42 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001289023 NM_001289025 NM_001289026 NM_001289027 NM_002287 NM_021706 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS12891 CCDS12892 CCDS74448 CCDS74449 CCDS74450 | ||||||||||||||||||
| HPRD | 04292 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||