InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAIR1

Summary

InnateDB Protein

IDBP-247079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAIR1

Protein Name

leukocyte-associated immunoglobulin-like receptor 1

Synonyms

CD305; LAIR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000375622

InnateDB Gene

IDBG-68573 (LAIR1)

Protein Structure

UniProt Annotation

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269PubMed:10229813, ECO:0000269PubMed:10764762, ECO:0000269PubMed:11069054, ECO:0000269PubMed:11160222, ECO:0000269PubMed:12072189, ECO:0000269PubMed:15939744, ECO:0000269PubMed:15950745, ECO:0000269PubMed:16380958, ECO:0000269PubMed:9285412, ECO:0000269PubMed:9692876}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10229813, ECO:0000269PubMed:11160222, ECO:0000269PubMed:9285412}; Single- pass type I membrane protein {ECO:0000269PubMed:10229813, ECO:0000269PubMed:11160222, ECO:0000269PubMed:9285412}.

Disease Associations

Tissue Specificity

Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. {ECO:0000269PubMed:10540327, ECO:0000269PubMed:12757266, ECO:0000269PubMed:14604962, ECO:0000269PubMed:15950745}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.