Version 5.4
Homo sapiens Gene: GGT7
Summary
InnateDB Gene IDBG-68807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT7
Gene Name gamma-glutamyltransferase 7
Synonyms D20S101; dJ18C9.2; GGT4; GGTL3; GGTL5
Species Homo sapiens
Ensembl Gene ENSG00000131067
Encoded Proteins
IDBP-68811
gamma-glutamyltransferase 7
IDBP-372435
gamma-glutamyltransferase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34844720-34872860
Strand Reverse strand
Band q11.22
Transcripts
ENST00000336431 ENSP00000338964
ENST00000427420 ENSP00000394993
ENST00000469018
ENST00000470952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0031362 anchored component of external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027603
View Gene Order
ENSBTAG00000013301
Not yet available
Pathways
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433738
RefSeq NM_178026
HUGO
OMIM
CCDS CCDS13242
HPRD 07488
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca