InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: H3F3B

Summary

InnateDB Gene

IDBG-68902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H3F3B

Gene Name

H3 histone, family 3B (H3.3B)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000132475

Encoded Proteins

IDBP-68904

H3 histone, family 3B (H3.3B)

IDBP-758070

IDBP-763805

IDBP-758364

IDBP-761339

IDBP-759606

IDBP-762105

IDBP-757744

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:75776434-75785893

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000254810	ENSP00000254810
ENST00000589949
ENST00000589417
ENST00000592643	ENSP00000467165
ENST00000593254
ENST00000586607	ENSP00000466020
ENST00000586270	ENSP00000465403
ENST00000587560	ENSP00000468714
ENST00000591893
ENST00000587171	ENSP00000468484
ENST00000591890	ENSP00000466663
ENST00000586518
ENST00000589599	ENSP00000465813

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0007596	blood coagulation
GO:0030307	positive regulation of cell growth

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0000788	nuclear nucleosome
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome