Version 5.4
Homo sapiens Gene: WBP2
Summary
InnateDB Gene IDBG-69042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WBP2
Gene Name WW domain binding protein 2
Synonyms WBP-2
Species Homo sapiens
Ensembl Gene ENSG00000132471
Encoded Proteins
IDBP-69044
WW domain binding protein 2
IDBP-384574
WW domain binding protein 2
IDBP-758676
IDBP-761476
IDBP-764607
IDBP-763446
IDBP-761552
IDBP-758619
IDBP-764875
IDBP-763203
IDBP-760380
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75845699-75856507
Strand Reverse strand
Band q25.1
Transcripts
ENST00000254806 ENSP00000254806
ENST00000433525 ENSP00000415251
ENST00000416574
ENST00000585462 ENSP00000467583
ENST00000592802
ENST00000593002 ENSP00000464768
ENST00000590221 ENSP00000466450
ENST00000591831 ENSP00000466999
ENST00000587374 ENSP00000464820
ENST00000587642
ENST00000589642 ENSP00000468793
ENST00000591399 ENSP00000467579
ENST00000590450
ENST00000589834
ENST00000589236
ENST00000586257 ENSP00000464782
ENST00000589241
ENST00000588373 ENSP00000465052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
Biological Process
GO:0045184 establishment of protein localization
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071391 cellular response to estrogen stimulus
GO:0071442 positive regulation of histone H3-K14 acetylation
Cellular Component
GO:0000790 nuclear chromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034341
View Gene Order
ENSBTAG00000008634
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q969T9
TrEMBL A0A024R8L1 A6NG10 K7EIJ0 K7ESN4
UniProt Splice Variant
Entrez Gene 23558
UniGene Hs.514489 Hs.594745 Hs.619535
RefSeq NM_012478
HUGO HGNC:12738
OMIM 606962
CCDS CCDS11731
HPRD 06097
IMGT
EMBL AC087289 AK293214 BC007452 BC010616 CH471099 U79458
GenPept AAD10951 AAH07452 AAH10616 BAG56753 EAW89325 EAW89328
RNA Seq Atlas 23558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca