InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BIRC2

Summary

InnateDB Gene

IDBG-69075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC2

Gene Name

baculoviral IAP repeat containing 2

Synonyms

API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48

Species

Homo sapiens

Ensembl Gene

ENSG00000110330

Encoded Proteins

IDBP-69077

baculoviral IAP repeat containing 2

IDBP-603000

baculoviral IAP repeat containing 2

IDBP-603042

baculoviral IAP repeat containing 2

IDBP-597207

baculoviral IAP repeat containing 2

IDBP-597963

baculoviral IAP repeat containing 2

IDBP-601520

baculoviral IAP repeat containing 2

IDBP-591168

baculoviral IAP repeat containing 2

IDBP-601168

baculoviral IAP repeat containing 2

IDBP-809724

baculoviral IAP repeat containing 2

IDBP-809726

baculoviral IAP repeat containing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18697935

BIRC2 regulates TNF-alpha(TNF)-mediated NF-kappaB activation by binding to TNFRSF1A (TNF receptor 1).

PMID 17220297

BIRC2 is the ubiquitin protein ligase for ASK1 ubiquitination, a protein that plays an essential role in tumour necrosis factor alpha (TNF-alpha)-induced mitogen-activated protein kinase signalling. BIRC2 is also responsible for regulating the duration of TNF signalling in primary cells expressing TNFR2.

PMID 19464198

BIRC2 and BIRC3 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.

PMID 20458734

BIRC2 plays a role in lipopolysaccharide (LPS)-induced autophagy in vascular endothelial cells (VECs).

PMID 21447281

BIRC2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

InnateDB Annotation from Orthologs

Summary

PMID 21447281

[Mus musculus] Birc2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

Entrez Gene

Summary

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102347211-102378670

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000227758	ENSP00000227758
ENST00000527808
ENST00000532832	ENSP00000432410
ENST00000530675	ENSP00000431723
ENST00000534646
ENST00000533742	ENSP00000433851
ENST00000532672	ENSP00000434979
ENST00000531259	ENSP00000436741
ENST00000527465	ENSP00000434708
ENST00000527910
ENST00000528344	ENSP00000434557
ENST00000534130
ENST00000613397	ENSP00000477613
ENST00000621637	ENSP00000484838

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 184 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	184 [view]
Protein-Protein	179 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007166	cell surface receptor signaling pathway
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0039535	regulation of RIG-I signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045471	response to ethanol
GO:0045595	regulation of cell differentiation
GO:0050727	regulation of inflammatory response
GO:0051291	protein heterooligomerization
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523	positive regulation of protein K63-linked ubiquitination
GO:1902524	positive regulation of protein K48-linked ubiquitination
GO:1902527	positive regulation of protein monoubiquitination
GO:2000116	regulation of cysteine-type endopeptidase activity
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0001741	XY body
GO:0005634	nucleus
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft