InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP20

Summary

InnateDB Gene

IDBG-69127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP20

Gene Name

matrix metallopeptidase 20

Synonyms

AI2A2; MMP-20

Species

Homo sapiens

Ensembl Gene

ENSG00000137674

Encoded Proteins

IDBP-69129

matrix metallopeptidase 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102576835-102625332

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000260228	ENSP00000260228
ENST00000542305
ENST00000544938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030163	protein catabolic process
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0070173	regulation of enamel mineralization
GO:0097186	amelogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018620

View Gene Order

ENSBTAG00000014251

Not yet available

Pathways

NETPATH

REACTOME

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O60882

TrEMBL

UniProt Splice Variant

Entrez Gene

9313

UniGene

Hs.591946

RefSeq

NM_004771

HUGO

HGNC:7167

OMIM

604629

CCDS

CCDS8318

HPRD

IMGT

EMBL

AP000851 AY673603 Y12779

GenPept

AAT70722 CAA73317

RNA Seq Atlas

9313