InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP20

Summary

InnateDB Protein

IDBP-69129.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP20

Protein Name

matrix metallopeptidase 20

Synonyms

AI2A2; MMP-20;

Species

Homo sapiens

Ensembl Protein

ENSP00000260228

InnateDB Gene

IDBG-69127 (MMP20)

Protein Structure

UniProt Annotation

Function

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. {ECO:0000269PubMed:10922468, ECO:0000269PubMed:9398237}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Amelogenesis imperfecta, hypomaturation type, 2A2 (AI2A2) [MIM:612529]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO:0000269PubMed:15744043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed specifically in the enamel organ.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030163	protein catabolic process
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0070173	regulation of enamel mineralization
GO:0097186	amelogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References