Version 5.4
Homo sapiens Gene: RFC4
Summary
InnateDB Gene IDBG-69139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFC4
Gene Name replication factor C (activator 1) 4, 37kDa
Synonyms A1; RFC37
Species Homo sapiens
Ensembl Gene ENSG00000163918
Encoded Proteins
IDBP-69141
replication factor C (activator 1) 4, 37kDa
IDBP-245579
replication factor C (activator 1) 4, 37kDa
IDBP-386443
replication factor C (activator 1) 4, 37kDa
IDBP-386444
replication factor C (activator 1) 4, 37kDa
IDBP-386445
replication factor C (activator 1) 4, 37kDa
IDBP-386447
replication factor C (activator 1) 4, 37kDa
IDBP-386448
replication factor C (activator 1) 4, 37kDa
IDBP-386450
replication factor C (activator 1) 4, 37kDa
IDBP-386452
replication factor C (activator 1) 4, 37kDa
IDBP-386453
replication factor C (activator 1) 4, 37kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186789880-186807058
Strand Reverse strand
Band q27.3
Transcripts
ENST00000296273 ENSP00000296273
ENST00000392481 ENSP00000376272
ENST00000433496 ENSP00000399769
ENST00000417876 ENSP00000401429
ENST00000418288 ENSP00000411300
ENST00000449502 ENSP00000394870
ENST00000447345 ENSP00000413065
ENST00000427785 ENSP00000407982
ENST00000448497 ENSP00000415099
ENST00000411792 ENSP00000399314
ENST00000479307
ENST00000494047
ENST00000460408
ENST00000489028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 83 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0008152 metabolic process
GO:0032201 telomere maintenance via semi-conservative replication
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022881
View Gene Order
ENSBTAG00000014727
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_828
G2/M Checkpoints pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03430
Mismatch repair pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.671735 Hs.732098
RefSeq NM_002916 NM_181573
HUGO
OMIM
CCDS CCDS3283
HPRD 00022
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca