InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFC4

Summary

InnateDB Protein

IDBP-245579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFC4

Protein Name

replication factor C (activator 1) 4, 37kDa

Synonyms

A1; RFC37;

Species

Homo sapiens

Ensembl Protein

ENSP00000376272

InnateDB Gene

IDBG-69139 (RFC4)

Protein Structure

UniProt Annotation

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	83 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0008152	metabolic process
GO:0032201	telomere maintenance via semi-conservative replication
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005654	nucleoplasm
GO:0005663	DNA replication factor C complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR013748 Replication factor C, C-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF08542

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35249