InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP3

Summary

InnateDB Gene

IDBG-69254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP3

Gene Name

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Synonyms

CHDS6; MMP-3; SL-1; STMY; STMY1; STR1

Species

Homo sapiens

Ensembl Gene

ENSG00000149968

Encoded Proteins

IDBP-69256

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

IDBP-382522

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

IDBP-586713

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102835801-102843803

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000299855	ENSP00000299855
ENST00000434103	ENSP00000398346
ENST00000524478	ENSP00000435255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0010727	negative regulation of hydrogen peroxide metabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0030574	collagen catabolic process
GO:0071230	cellular response to amino acid stimulus