InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LGALS1

Summary

InnateDB Gene

IDBG-6929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS1

Gene Name

lectin, galactoside-binding, soluble, 1

Synonyms

GAL1; GBP

Species

Homo sapiens

Ensembl Gene

ENSG00000100097

Encoded Proteins

IDBP-6931

lectin, galactoside-binding, soluble, 1

IDBP-375701

lectin, galactoside-binding, soluble, 1

IDBP-375703

lectin, galactoside-binding, soluble, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19561030

LGALS1, the prototype of a family of beta-galactoside-binding proteins, is involved in monocyte chemoattraction at sites of inflammation where it stimulates monocyte migration in a dose-dependent manner via the p44/42 MAP kinase pathway.

PMID 26589797

LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.

Entrez Gene

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:37675608-37679806

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000215909	ENSP00000215909
ENST00000425542	ENSP00000404414
ENST00000454173	ENSP00000388296
ENST00000464120
ENST00000480207
ENST00000489315
ENST00000472321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.

Experimentally validated
Total	59 [view]
Protein-Protein	57 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016936	galactoside binding
GO:0030246	carbohydrate binding
GO:0030395	lactose binding
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010977	negative regulation of neuron projection development
GO:0031295	T cell costimulation
GO:0033555	multicellular organismal response to stress
GO:0034120	positive regulation of erythrocyte aggregation
GO:0042493	response to drug
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045445	myoblast differentiation
GO:0048678	response to axon injury
GO:0071333	cellular response to glucose stimulus
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068220

View Gene Order

ENSBTAG00000015089

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

F8WCQ5

UniProt Splice Variant

Entrez Gene

3956

UniGene

RefSeq

NM_002305

HUGO

HGNC:6561

OMIM

150570

CCDS

CCDS13954

HPRD

01040

IMGT

EMBL

Z83844

GenPept

RNA Seq Atlas

3956