Version 5.4
Bos taurus Gene: LGALS1
Summary
InnateDB Gene IDBG-641441.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS1
Gene Name Galectin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015089
Encoded Proteins
IDBP-693806
Galectin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19561030
[Homo sapiens] LGALS1, the prototype of a family of beta-galactoside-binding proteins, is involved in monocyte chemoattraction at sites of inflammation where it stimulates monocyte migration in a dose-dependent manner via the p44/42 MAP kinase pathway.
PMID 26589797
[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100097:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110014543-110017878
Strand Forward strand
Band
Transcripts
ENSBTAT00000020080 ENSBTAP00000020080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016936 galactoside binding
GO:0030246 carbohydrate binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002317 plasma cell differentiation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0031295 T cell costimulation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045445 myoblast differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100097
View Gene Order
ENSMUSG00000068220
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt P11116
TrEMBL Q862F2 Q862G9
UniProt Splice Variant
Entrez Gene 326598
UniGene Bt.112244
RefSeq NM_175782
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB099023 AB099039 AB099046 BC103156 X14330
GenPept AAI03157 BAC56513 BAC56529 BAC56536 CAA32508
RNA Seq Atlas 326598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca