Version 5.4
Homo sapiens Gene: SRP68
Summary
InnateDB Gene IDBG-69300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRP68
Gene Name signal recognition particle 68kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167881
Encoded Proteins
IDBP-69302
signal recognition particle 68kDa
IDBP-586660
signal recognition particle 68kDa
IDBP-762684
IDBP-759087
IDBP-811566
signal recognition particle 68kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:76038775-76072653
Strand Reverse strand
Band q25.1
Transcripts
ENST00000307877 ENSP00000312066
ENST00000539137 ENSP00000446136
ENST00000542536
ENST00000586859
ENST00000588736
ENST00000591272 ENSP00000467765
ENST00000590833
ENST00000587864
ENST00000592704 ENSP00000466791
ENST00000585539
ENST00000588643
ENST00000602720 ENSP00000473613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 27 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005047 signal recognition particle binding
GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0042493 response to drug
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020780
View Gene Order
ENSBTAG00000009228
Not yet available
Pathways
NETPATH
REACTOME
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514495
RefSeq NM_001260502 NM_001260503 NM_014230
HUGO
OMIM
CCDS CCDS11738 CCDS58600 CCDS58601
HPRD 05331
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca