Version 5.4
Mus musculus Gene: Srp68
Summary
InnateDB Gene IDBG-214435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srp68
Gene Name signal recognition particle 68
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020780
Encoded Proteins
IDBP-214437
signal recognition particle 68
IDBP-268797
signal recognition particle 68
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167881:
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116245166-116274217
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000021133 ENSMUSP00000021133
ENSMUST00000106425 ENSMUSP00000102033
ENSMUST00000127205
ENSMUST00000128808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005047 signal recognition particle binding
GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0042493 response to drug
Cellular Component
GO:0005730 nucleolus
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167881
View Gene Order
ENSBTAG00000009228
Not yet available
Pathways
NETPATH
REACTOME
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_233572
Gene Expression pathway
KEGG
mmu03060
Protein export pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt Q8BMA6
TrEMBL A2AAN2 Q8K258
UniProt Splice Variant
Entrez Gene 217337
UniGene Mm.29655
RefSeq NM_146032
OMIM
CCDS CCDS25662
HPRD
IMGT
MGI ID MGI:1917447
MGI Symbol Srp68
EMBL AK033010 AL645861 AL669925 BC033573 BC070422 CH466558
GenPept AAH33573 AAH70422 BAC28124 CAM16383 CAM16795 EDL34568
RNA Seq Atlas 217337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca