Version 5.4
Homo sapiens Gene: WDR33
Summary
InnateDB Gene IDBG-69316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR33
Gene Name WD repeat domain 33
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136709
Encoded Proteins
IDBP-69318
WD repeat domain 33
IDBP-244482
WD repeat domain 33
IDBP-294320
WD repeat domain 33
IDBP-294319
WD repeat domain 33
IDBP-385715
WD repeat domain 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127701022-127811187
Strand Reverse strand
Band q14.3
Transcripts
ENST00000322313 ENSP00000325377
ENST00000393006 ENSP00000376730
ENST00000409658 ENSP00000387186
ENST00000408998 ENSP00000386861
ENST00000436787 ENSP00000397547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006301 postreplication repair
GO:0006397 mRNA processing
GO:0007283 spermatogenesis
Cellular Component
GO:0005581 collagen trimer
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024400
View Gene Order
ENSBTAG00000005987
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9C0J8
TrEMBL B9A053
UniProt Splice Variant
Entrez Gene 84826
UniGene Hs.345849 Hs.554831 Hs.604360 Hs.639701 Hs.700855
RefSeq NM_001006623 NM_001006622 NM_018383
HUGO HGNC:25651
OMIM
CCDS CCDS42746 CCDS2150 CCDS46407
HPRD 11680
IMGT
EMBL AB044749 AC006011 AK002156 AK223319 AL834365 BC005401 BC013990 BC068484 CH471103
GenPept AAH05401 AAH13990 AAH68484 AAX82033 BAA92113 BAB32435 BAD97039 CAH10688 EAW95342 EAW95343
RNA Seq Atlas 55339 84826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca