InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR33

Summary

InnateDB Protein

IDBP-294320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR33

Protein Name

WD repeat domain 33

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387186

InnateDB Gene

IDBG-69316 (WDR33)

Protein Structure

UniProt Annotation

Function

Essential for both cleavage and polyadenylation of pre- mRNA 3' ends. {ECO:0000269PubMed:19217410}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11162572, ECO:0000269PubMed:19217410}.

Disease Associations

Tissue Specificity

Most highly expressed in testis. {ECO:0000269PubMed:11162572}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006301	postreplication repair
GO:0006397	mRNA processing
GO:0007283	spermatogenesis

Cellular Component

GO:0005581	collagen trimer
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain

PFAM

PF00400

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C0J8

PhosphoSite

PhosphoSite-Q9C0J8

TrEMBL

B9A053

UniProt Splice Variant

Entrez Gene

84826

UniGene

Hs.700855

RefSeq

NP_001006623

HUGO

HGNC:25651

OMIM

CCDS

CCDS46407

HPRD

11680

IMGT

EMBL

AB044749 AC006011 AK002156 AK223319 AL834365 BC005401 BC013990 BC068484 CH471103

GenPept

AAH05401 AAH13990 AAH68484 AAX82033 BAA92113 BAB32435 BAD97039 CAH10688 EAW95342 EAW95343