Version 5.4
Homo sapiens Gene: MMP13
Summary
InnateDB Gene IDBG-69325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP13
Gene Name matrix metallopeptidase 13 (collagenase 3)
Synonyms CLG3; MANDP1; MMP-13
Species Homo sapiens
Ensembl Gene ENSG00000137745
Encoded Proteins
IDBP-69327
matrix metallopeptidase 13 (collagenase 3)
IDBP-69329
matrix metallopeptidase 13 (collagenase 3)
IDBP-807018
matrix metallopeptidase 13 (collagenase 3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102942995-102955734
Strand Reverse strand
Band q22.2
Transcripts
ENST00000340273 ENSP00000339672
ENST00000260302 ENSP00000260302
ENST00000615555 ENSP00000482883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 4 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001958 endochondral ossification
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030282 bone mineralization
GO:0030574 collagen catabolic process
GO:0044267 cellular protein metabolic process
GO:0051216 cartilage development
GO:0060349 bone morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050578
View Gene Order
ENSBTAG00000015059
Not yet available
Pathways
NETPATH
REACTOME
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Cross-References
SwissProt P45452
TrEMBL Q6LBE5
UniProt Splice Variant
Entrez Gene 4322
UniGene Hs.2936 Hs.623032
RefSeq NM_002427
HUGO HGNC:7159
OMIM 600108
CCDS CCDS8324
HPRD 02522
IMGT
EMBL AK292211 AK315341 AY741163 BC067522 BC067523 BC074807 BC074808 X75308 X81334 X81640
GenPept AAH67522 AAH67523 AAH74807 AAH74808 AAU13907 BAF84900 BAG37740 CAA53056 CAA57108 CAA57296
RNA Seq Atlas 4322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca