InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP13

Summary

InnateDB Protein

IDBP-69329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP13

Protein Name

matrix metallopeptidase 13 (collagenase 3)

Synonyms

CLG3; MANDP1; MMP-13;

Species

Homo sapiens

Ensembl Protein

ENSP00000260302

InnateDB Gene

IDBG-69325 (MMP13)

Protein Structure

UniProt Annotation

Function

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269PubMed:16167086, ECO:0000269PubMed:17623656, ECO:0000269PubMed:19422229, ECO:0000269PubMed:19615667, ECO:0000269PubMed:20726512, ECO:0000269PubMed:22689580, ECO:0000269PubMed:23810497, ECO:0000269PubMed:8207000, ECO:0000269PubMed:8576151, ECO:0000269PubMed:8603731, ECO:0000269PubMed:8663255, ECO:0000269PubMed:9065415}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305PubMed:8576151}. Secreted {ECO:0000269PubMed:8576151}.

Disease Associations

Spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]: A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age. {ECO:0000269PubMed:16167086}. Note=The disease is caused by mutations affecting the gene represented in this entry.Metaphyseal anadysplasia 1 (MANDP1) [MIM:602111]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. {ECO:0000269PubMed:19615667}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269PubMed:8207000, ECO:0000269PubMed:8798568, ECO:0000269PubMed:9056642, ECO:0000269PubMed:9562863}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	4 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001958	endochondral ossification
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030282	bone mineralization
GO:0030574	collagen catabolic process
GO:0044267	cellular protein metabolic process
GO:0051216	cartilage development
GO:0060349	bone morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References