InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GALR2

Summary

InnateDB Gene

IDBG-69355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALR2

Gene Name

galanin receptor 2

Synonyms

GAL2-R; GALNR2; GALR-2

Species

Homo sapiens

Ensembl Gene

ENSG00000182687

Encoded Proteins

IDBP-69357

galanin receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:76074794-76077541

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000329003

ENSP00000329684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004966	galanin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0006936	muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0007586	digestion
GO:0007611	learning or memory
GO:0007631	feeding behavior
GO:0031175	neuron projection development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020793

View Gene Order

ENSBTAG00000024910

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

O43603

TrEMBL

UniProt Splice Variant

Entrez Gene

8811

UniGene

Hs.666366

RefSeq

NM_003857

HUGO

HGNC:4133

OMIM

603691

CCDS

CCDS11739

HPRD

IMGT

EMBL

AF040630 AF042782 AF058762 AF080586 BC069130 BC074914 BC074915 BC109051 BC109052 CH471099 EF577401

GenPept

AAC18118 AAC36587 AAC39634 AAD08671 AAH69130 AAH74914 AAH74915 AAI09052 AAI09053 ABQ52421 EAW89364

RNA Seq Atlas

8811