InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALR2

Summary

InnateDB Protein

IDBP-69357.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALR2

Protein Name

galanin receptor 2

Synonyms

GAL2-R; GALNR2; GALR-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000329684

InnateDB Gene

IDBG-69355 (GALR2)

Protein Structure

UniProt Annotation

Function

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). {ECO:0000269PubMed:24517231}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004966	galanin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0006936	muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0007586	digestion
GO:0007611	learning or memory
GO:0007631	feeding behavior
GO:0031175	neuron projection development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000405 Galanin receptor family
IPR003907 Galanin receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10320
PF10324

PRINTS

PR00237
PR00663
PR01419

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43603