Version 5.4
Homo sapiens Gene: TSPYL2
Summary
InnateDB Gene IDBG-69479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPYL2
Gene Name TSPY-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184205
Encoded Proteins
IDBP-69481
TSPY-like 2
IDBP-713483
IDBP-713385
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:53082367-53088540
Strand Forward strand
Band p11.22
Transcripts
ENST00000375442 ENSP00000364591
ENST00000463525
ENST00000553557
ENST00000556808
ENST00000579390 ENSP00000462287
ENST00000578306 ENSP00000462635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000182 rDNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007049 cell cycle
GO:0008156 negative regulation of DNA replication
GO:0009966 regulation of signal transduction
GO:0016568 chromatin modification
GO:0030308 negative regulation of cell growth
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0045786 negative regulation of cell cycle
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041096
View Gene Order
ENSBTAG00000017783
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.136164 Hs.592916
RefSeq NM_022117
HUGO
OMIM
CCDS CCDS14350
HPRD 06713
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca