Version 5.4
Homo sapiens Protein: TSPYL2
Summary
InnateDB Protein IDBP-69481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPYL2
Protein Name TSPY-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364591
InnateDB Gene IDBG-69479 (TSPYL2)
Protein Structure
UniProt Annotation
Function Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269PubMed:11395479, ECO:0000269PubMed:17317670}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11318608, ECO:0000269PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269PubMed:11149944, ECO:0000269PubMed:11318608, ECO:0000269PubMed:12393179, ECO:0000269PubMed:15241014}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000182 rDNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007049 cell cycle
GO:0008156 negative regulation of DNA replication
GO:0009966 regulation of signal transduction
GO:0016568 chromatin modification
GO:0030308 negative regulation of cell growth
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0045786 negative regulation of cell cycle
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR002164 Nucleosome assembly protein (NAP)
PFAM PF00956
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2G4
PhosphoSite PhosphoSite-Q9H2G4
TrEMBL
UniProt Splice Variant
Entrez Gene 64061
UniGene Hs.592916
RefSeq NP_071400
HUGO HGNC:24358
OMIM 300564
CCDS CCDS14350
HPRD 06713
IMGT
EMBL AB015345 AF254794 AF273046 AL713652 AY040871 BC001566 BC024270 BX322635
GenPept AAG34906 AAG53596 AAH01566 AAH24270 AAK72407 BAA34802 CAD28461 CAI42531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca