Version 5.4
Homo sapiens Gene: NCR1
Summary
InnateDB Gene IDBG-69753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCR1
Gene Name natural cytotoxicity triggering receptor 1
Synonyms CD335; LY94; NK-p46; NKP46
Species Homo sapiens
Ensembl Gene ENSG00000189430
Encoded Proteins
IDBP-69755
natural cytotoxicity triggering receptor 1
IDBP-69757
natural cytotoxicity triggering receptor 1
IDBP-69759
natural cytotoxicity triggering receptor 1
IDBP-69761
natural cytotoxicity triggering receptor 1
IDBP-761360
IDBP-764838
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54906150-54916140
Strand Forward strand
Band q13.42
Transcripts
ENST00000291890 ENSP00000291890
ENST00000338835 ENSP00000339515
ENST00000350790 ENSP00000344358
ENST00000357397 ENSP00000349972
ENST00000601903
ENST00000594765 ENSP00000471986
ENST00000601137
ENST00000598576 ENSP00000469750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
Biological Process
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0030101 natural killer cell activation
GO:0035556 intracellular signal transduction
GO:0042269 regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016514 SWI/SNF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062524
View Gene Order
ENSBTAG00000045529
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt O76036
TrEMBL
UniProt Splice Variant
Entrez Gene 9437
UniGene Hs.97084
RefSeq NM_001145457 NM_001145458 NM_001242356 NM_001242357 NM_004829
HUGO HGNC:6731
OMIM 604530
CCDS CCDS12911 CCDS46181 CCDS46182 CCDS56103
HPRD 05167
IMGT
EMBL AJ001383 AJ006121 AJ006122 AJ006123 AY346373 BC064806 CH471135 CU151839 CU459006
GenPept AAH64806 AAQ54328 CAA04714 CAA06872 CAA06873 CAA06874 CAQ09214 CAQ09215 CAQ09216 CAQ09217 CAX14949 CAX14950 CAX14951 CAX14952 EAW72308 EAW72310 EAW72311
RNA Seq Atlas 9437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca