InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCR1

Summary

InnateDB Protein

IDBP-69761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCR1

Protein Name

natural cytotoxicity triggering receptor 1

Synonyms

CD335; LY94; NK-p46; NKP46;

Species

Homo sapiens

Ensembl Protein

ENSP00000349972

InnateDB Gene

IDBG-69753 (NCR1)

Protein Structure

UniProt Annotation

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269PubMed:9730896}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Selectively expressed by both resting and activated NK cells. {ECO:0000269PubMed:9730896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0030101	natural killer cell activation
GO:0035556	intracellular signal transduction
GO:0042269	regulation of natural killer cell mediated cytotoxicity