Version 5.4
Homo sapiens Gene: HBZ
Summary
InnateDB Gene IDBG-6987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBZ
Gene Name hemoglobin, zeta
Synonyms HBZ-T1; HBZ1
Species Homo sapiens
Ensembl Gene ENSG00000130656
Encoded Proteins
IDBP-6989
hemoglobin, zeta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5\' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3\'. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:152687-154503
Strand Forward strand
Band p13.3
Transcripts
ENST00000252951 ENSP00000252951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0015671 oxygen transport
GO:0043249 erythrocyte maturation
Cellular Component
GO:0005833 hemoglobin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055609
View Gene Order
ENSBTAG00000034024
Not yet available
Cross-References
SwissProt P02008
TrEMBL
UniProt Splice Variant
Entrez Gene 3050
UniGene
RefSeq NM_005332 XM_005255288
HUGO HGNC:4835
OMIM 142310
CCDS CCDS10397
HPRD
IMGT
EMBL AE006462 BC027892 CH471112 CR456848 J00182 M24173 Z84721
GenPept AAA61306 AAB59406 AAH27892 AAK61214 CAB06552 CAG33129 EAW85864
RNA Seq Atlas 3050

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca