InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HBZ

Summary

InnateDB Protein

IDBP-6989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HBZ

Protein Name

hemoglobin, zeta

Synonyms

HBZ-T1; HBZ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000252951

InnateDB Gene

IDBG-6987 (HBZ)

Protein Structure

UniProt Annotation

Function

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in fetal erythrocytes (at protein level). {ECO:0000269PubMed:6171809, ECO:0000269PubMed:6539334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005344	oxygen transporter activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0019825	oxygen binding
GO:0020037	heme binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0015671	oxygen transport
GO:0043249	erythrocyte maturation

Cellular Component

GO:0005833

hemoglobin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000971 Globin
IPR002335 Myoglobin
IPR002338 Haemoglobin, alpha
IPR002339 Haemoglobin, pi
IPR002340 Haemoglobin, zeta
IPR009050 Globin-like

PFAM

PF00042

PRINTS

PR00613
PR00612
PR00815
PR00816

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P02008

PhosphoSite

PhosphoSite-P02008

TrEMBL

UniProt Splice Variant

Entrez Gene

3050

UniGene

RefSeq

NP_005323

HUGO

HGNC:4835

OMIM

142310

CCDS

CCDS10397

HPRD

00794

IMGT

EMBL

AE006462 BC027892 CH471112 CR456848 J00182 M24173 Z84721

GenPept

AAA61306 AAB59406 AAH27892 AAK61214 CAB06552 CAG33129 EAW85864