Version 5.4
Homo sapiens Gene: SLN
Summary
InnateDB Gene IDBG-70035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLN
Gene Name sarcolipin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170290
Encoded Proteins
IDBP-70037
sarcolipin
IDBP-597151
sarcolipin
IDBP-595745
sarcolipin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:107707378-107719693
Strand Reverse strand
Band q22.3
Transcripts
ENST00000305991 ENSP00000304707
ENST00000531293 ENSP00000435380
ENST00000525934 ENSP00000434189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0030234 enzyme regulator activity
GO:0051117 ATPase binding
Biological Process
GO:0006816 calcium ion transport
GO:0043086 negative regulation of catalytic activity
GO:0043242 negative regulation of protein complex disassembly
GO:0051924 regulation of calcium ion transport
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0090281 negative regulation of calcium ion import
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1901077 regulation of relaxation of muscle
GO:1901877 negative regulation of calcium ion binding
GO:1901881 positive regulation of protein depolymerization
GO:1901894 regulation of calcium-transporting ATPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000042045
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003063
HUGO
OMIM
CCDS CCDS31667
HPRD 03729
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca