Version 5.4
Homo sapiens Protein: SLN
Summary
InnateDB Protein IDBP-70037.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLN
Protein Name sarcolipin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000304707
InnateDB Gene IDBG-70035 (SLN)
Protein Structure
UniProt Annotation
Function Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. {ECO:0000250, ECO:0000269PubMed:11781085, ECO:0000269PubMed:9575189}.
Subcellular Localization Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0030234 enzyme regulator activity
GO:0051117 ATPase binding
Biological Process
GO:0006816 calcium ion transport
GO:0043086 negative regulation of catalytic activity
GO:0043242 negative regulation of protein complex disassembly
GO:0051924 regulation of calcium ion transport
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0090281 negative regulation of calcium ion import
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1901077 regulation of relaxation of muscle
GO:1901877 negative regulation of calcium ion binding
GO:1901881 positive regulation of protein depolymerization
GO:1901894 regulation of calcium-transporting ATPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR008028 Sarcolipin
PFAM PF05366
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00631
PhosphoSite PhosphoSite-O00631
TrEMBL
UniProt Splice Variant
Entrez Gene 6588
UniGene
RefSeq NP_003054
HUGO HGNC:11089
OMIM 602203
CCDS CCDS31667
HPRD 03729
IMGT
EMBL AK312097 BC094685 BC104150 BC104185 BC113930 BC113987 CR450290 U96093 U96094
GenPept AAB86980 AAB86981 AAH94685 AAI04151 AAI04186 AAI13931 AAI13988 BAG35033 CAG29286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca