Version 5.4
Homo sapiens Gene: TMC6
Summary
InnateDB Gene IDBG-70375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMC6
Gene Name transmembrane channel-like 6
Synonyms EV1; EVER1; EVIN1; LAK-4P
Species Homo sapiens
Ensembl Gene ENSG00000141524
Encoded Proteins
IDBP-70377
transmembrane channel-like 6
IDBP-70379
transmembrane channel-like 6
IDBP-245598
transmembrane channel-like 6
IDBP-758215
IDBP-759109
IDBP-762283
IDBP-757812
IDBP-762983
IDBP-763482
IDBP-764389
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78110458-78132407
Strand Reverse strand
Band q25.3
Transcripts
ENST00000322914 ENSP00000313408
ENST00000306591 ENSP00000306405
ENST00000392467 ENSP00000376260
ENST00000590934
ENST00000588087
ENST00000590602 ENSP00000465261
ENST00000588792
ENST00000586271
ENST00000591594
ENST00000592594 ENSP00000467016
ENST00000589553 ENSP00000465359
ENST00000585849
ENST00000589271 ENSP00000468255
ENST00000593044
ENST00000592063 ENSP00000466885
ENST00000591436 ENSP00000464853
ENST00000587480
ENST00000592076
ENST00000590162
ENST00000591756
ENST00000586697
ENST00000589933
ENST00000586126 ENSP00000466159
ENST00000590494
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025572
View Gene Order
ENSBTAG00000018661
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632227
RefSeq NM_001127198 NM_007267 XM_005256995 XM_005256996
HUGO
OMIM
CCDS CCDS32748
HPRD 08386
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca