Version 5.4
| Mus musculus Gene: Dynlt1f | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-704047.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Dynlt1f | ||||||||||||
| Gene Name | dynein light chain Tctex-type 1F | ||||||||||||
| Synonyms | AGS2; Dynlt1; Tctex-1; Tctex1 | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000095677 | ||||||||||||
| Encoded Proteins | |||||||||||||
| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146425:
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 [PubMed 15992542]).[supplied by OMIM, Mar 2008] This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 17:6648941-6655939 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | A1 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME | |||||||||||||
| KEGG | |||||||||||||
| INOH | |||||||||||||
| PID NCI |
Neurotrophic factor-mediated Trk receptor signaling
Lissencephaly gene (LIS1) in neuronal migration and development
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| Cross-References | |||||||||||||
| SwissProt | P51807 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 21648 | ||||||||||||
| UniGene | |||||||||||||
| RefSeq | NM_001166627 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS57043 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:3780996 | ||||||||||||
| MGI Symbol | Dynlt1f | ||||||||||||
| EMBL | AK133788 AK153971 AK168478 BC043018 BC087868 M25825 | ||||||||||||
| GenPept | AAA40408 AAH43018 AAH87868 BAE21842 BAE32288 BAE40367 | ||||||||||||
| RNA Seq Atlas | 100040531 100040563 100310872 21648 | ||||||||||||