InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DYNLT1

Summary

InnateDB Gene

IDBG-635357.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNLT1

Gene Name

Dynein light chain Tctex-type 1

Synonyms

TCTEL1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004472

Encoded Proteins

IDBP-687195

Dynein light chain Tctex-type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146425:
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 [PubMed 15992542]).[supplied by OMIM, Mar 2008]
This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:96486514-96497234

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005869

ENSBTAP00000005869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0043001	Golgi to plasma membrane protein transport
GO:0050768	negative regulation of neurogenesis
GO:0051301	cell division

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0030286	dynein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000146425

View Gene Order

ENSMUSG00000095677

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

P63171

TrEMBL

UniProt Splice Variant

Entrez Gene

282380

UniGene

Bt.64528

RefSeq

NM_174620

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF067370 BC108160

GenPept

AAC39268 AAI08161

RNA Seq Atlas

282380