Version 5.4
Mus musculus Gene: Asmt
Summary
InnateDB Gene IDBG-704083.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asmt
Gene Name acetylserotonin O-methyltransferase
Synonyms Hiomt
Species Mus musculus
Ensembl Gene ENSMUSG00000093806
Encoded Proteins
IDBP-714931
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) inactivate this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:170672644-170678054
Strand Forward strand
Band F5
Transcripts
ENSMUST00000178693 ENSMUSP00000137135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0017096 acetylserotonin O-methyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0008152 metabolic process
GO:0030187 melatonin biosynthetic process
GO:0032259 methylation
GO:2000019 negative regulation of male gonad development
Cellular Component
GO:0005575 cellular_component
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_218437
Serotonin and melatonin biosynthesis pathway
REACT_215158
Amine-derived hormones pathway
KEGG
mmu00380
Tryptophan metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.486144
RefSeq NM_001199212
OMIM
CCDS
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca