InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asmt

Summary

InnateDB Protein

IDBP-714931.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asmt

Protein Name

Synonyms

Hiomt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137135

InnateDB Gene

IDBG-704083 (Asmt)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed predominantly in the pineal gland. very low expression, if any, in the retina. {ECO:0000269PubMed:20308563}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0017096	acetylserotonin O-methyltransferase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0008152	metabolic process
GO:0030187	melatonin biosynthetic process
GO:0032259	methylation
GO:2000019	negative regulation of male gonad development

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:96090

InterPro

IPR001077 O-methyltransferase, family 2
IPR013216 Methyltransferase type 11
IPR016461 Caffeate O-methyltransferase (COMT) family
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00891
PF08241

PRINTS

PIRSF

PIRSF005739

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

D3KU66