Version 5.4
| Homo sapiens Gene: MGAT5 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-70492.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | MGAT5 | ||||||||||
| Gene Name | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | ||||||||||
| Synonyms | GNT-V; GNT-VA | ||||||||||
| Species | Homo sapiens | ||||||||||
| Ensembl Gene | ENSG00000152127 | ||||||||||
| Encoded Proteins |
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 2:134119983-134454621 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | q21.2 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
N-Glycan antennae elongation pathway
Transport to the Golgi and subsequent modification pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Metabolism of proteins pathway
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| KEGG |
N-Glycan biosynthesis pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q09328 | ||||||||||
| TrEMBL | Q53SM9 Q53SV8 Q53SZ9 Q71VM6 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 4249 | ||||||||||
| UniGene | Hs.4988 Hs.737717 | ||||||||||
| RefSeq | XM_005263666 XM_005263668 XM_005263669 XM_005263670 XM_006712534 XM_006712535 NM_002410 | ||||||||||
| HUGO | HGNC:7049 | ||||||||||
| OMIM | 601774 | ||||||||||
| CCDS | CCDS2171 | ||||||||||
| HPRD | 03467 | ||||||||||
| IMGT | |||||||||||
| EMBL | AC013276 AC013718 AC016906 AF004882 AF113921 CH471058 D17716 | ||||||||||
| GenPept | AAB81939 AAD22449 AAX93248 AAY14747 AAY14791 BAA04570 EAX11657 EAX11658 | ||||||||||
| RNA Seq Atlas | 4249 | ||||||||||