Mus musculus Gene: Tnfsf12 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-708803.2 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Tnfsf12 | ||||||||||
Gene Name | tumor necrosis factor (ligand) superfamily, member 12 | ||||||||||
Synonyms | Apo3l; Dr3l; Dr3lg; Tweak | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000097328 | ||||||||||
Encoded Proteins | |||||||||||
Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene represents read-through transcription between neighboring genes encoding tumor necrosis factor family members. This results a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The homologous fusion protein in human is known to be membrane-anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Oct 2010] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 11:69686250-69695849 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | B3 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
No orthologs found for this gene | |||||||||||
Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME |
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
HuR stabilizes mRNA pathway
Gene Expression pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Mm.401737 Mm.8983 | ||||||||||
RefSeq | NM_001034097 NM_001159503 NM_011614 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS24906 CCDS48828 CCDS24907 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | |||||||||||
MGI Symbol | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||