Version 5.4
Mus musculus Gene: Tnfsf12
Summary
InnateDB Gene IDBG-708803.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfsf12
Gene Name tumor necrosis factor (ligand) superfamily, member 12
Synonyms Apo3l; Dr3l; Dr3lg; Tweak
Species Mus musculus
Ensembl Gene ENSMUSG00000097328
Encoded Proteins
IDBP-717888
IDBP-717539
IDBP-717138
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents read-through transcription between neighboring genes encoding tumor necrosis factor family members. This results a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The homologous fusion protein in human is known to be membrane-anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69686250-69695849
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000181261 ENSMUSP00000137916
ENSMUST00000180587 ENSMUSP00000137973
ENSMUST00000181810 ENSMUSP00000137972
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0030154 cell differentiation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198691
HuR stabilizes mRNA pathway
REACT_233572
Gene Expression pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.401737 Mm.8983
RefSeq NM_001034097 NM_001159503 NM_011614
OMIM
CCDS CCDS24906 CCDS48828 CCDS24907
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca