InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfsf12

Summary

InnateDB Protein

IDBP-717138.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf12

Protein Name

Synonyms

Apo3l; Dr3l; Dr3lg; Tweak;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137972

InnateDB Gene

IDBG-708803 (Tnfsf12)

Protein Structure

UniProt Annotation

Function

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0030154	cell differentiation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm