InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNK3

Summary

InnateDB Gene

IDBG-71035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNK3

Gene Name

WNK lysine deficient protein kinase 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000196632

Encoded Proteins

IDBP-71037

WNK lysine deficient protein kinase 3

IDBP-71039

WNK lysine deficient protein kinase 3

IDBP-71043

WNK lysine deficient protein kinase 3

IDBP-373631

WNK lysine deficient protein kinase 3

IDBP-812723

WNK lysine deficient protein kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:54192823-54358642

Strand

Reverse strand

Band

p11.22

Transcripts

ENST00000375169	ENSP00000364312
ENST00000354646	ENSP00000346667
ENST00000375159	ENSP00000364301
ENST00000458404	ENSP00000401816
ENST00000620763	ENSP00000481888

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019869	chloride channel inhibitor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0010765	positive regulation of sodium ion transport
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0051928	positive regulation of calcium ion transport
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:2000021	regulation of ion homeostasis
GO:2000651	positive regulation of sodium ion transmembrane transporter activity
GO:2000682	positive regulation of rubidium ion transport
GO:2000688	positive regulation of rubidium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005912	adherens junction
GO:0005923	tight junction

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9BYP7

TrEMBL

B1AQN8

UniProt Splice Variant

Entrez Gene

65267

UniGene

Hs.599742 Hs.638054 Hs.92423

RefSeq

NM_001002838 NM_020922 XM_006724593 XM_006724594

HUGO

HGNC:14543

OMIM

300358

CCDS

CCDS14357 CCDS35302

HPRD

02289

IMGT

EMBL

AB046786 AJ409088 AL049793 AL591766 AY082340 AY352048 Z84469

GenPept

AAL99253 AAR89465 BAB13392 CAC32455 CAI40707 CAI40708 CAI42732 CAI42733 CAI43128 CAI43129

RNA Seq Atlas

65267