Version 5.4
| Homo sapiens Gene: NLRP4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-71189.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | NLRP4 | ||||||||||||||||||
| Gene Name | NLR family, pyrin domain containing 4 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000160505 | ||||||||||||||||||
| Encoded Proteins |
NLR family, pyrin domain containing 4
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
NLRP4 binds with NLRC4 through NACHT domain, which by mediating hetero-oligomerization, creates protein-interaction networks that potentially modulate immune responses to invading pathogens.
NLRP4 regulates the activation of type I interferon triggered by dsRNA or dsDNA.
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| Entrez Gene | |||||||||||||||||||
| Summary |
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:55836578-55881854 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q13.43 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
TNFalpha pathway
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| REACTOME |
IRF3 mediated activation of type 1 IFN pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
STING mediated induction of host immune responses pathway
IRF3-mediated induction of type I IFN pathway
Innate Immune System pathway
Regulation of innate immune responses to cytosolic DNA pathway
Immune System pathway
Cytosolic sensors of pathogen-associated DNA pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.631533 | ||||||||||||||||||
| RefSeq | NM_134444 XM_006723042 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS12936 | ||||||||||||||||||
| HPRD | 09619 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||