Version 5.4
Homo sapiens Gene: HIST1H1B
Summary
InnateDB Gene IDBG-71233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1B
Gene Name histone cluster 1, H1b
Synonyms H1; H1.5; H1B; H1F5; H1s-3
Species Homo sapiens
Ensembl Gene ENSG00000184357
Encoded Proteins
IDBP-71235
histone cluster 1, H1b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:27866849-27867529
Strand Reverse strand
Band p22.1
Transcripts
ENST00000331442 ENSP00000330074
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0031490 chromatin DNA binding
GO:0042826 histone deacetylase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0030307 positive regulation of cell growth
GO:0050821 protein stabilization
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0071169 establishment of protein localization to chromatin
Cellular Component
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_13462
Activation of DNA fragmentation factor pathway
REACT_995
Apoptotic execution phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_1213
Apoptosis induced DNA fragmentation pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_578
Apoptosis pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P16401
TrEMBL
UniProt Splice Variant
Entrez Gene 3009
UniGene
RefSeq NM_005322
HUGO HGNC:4719
OMIM 142711
CCDS CCDS4635
HPRD
IMGT
EMBL AF531304 BC069101 BC101581 BC101583 X83509 Z98744
GenPept AAH69101 AAI01582 AAI01584 AAN06704 CAA58498 CAB11421
RNA Seq Atlas 3009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca