InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIST1H1B

Summary

InnateDB Protein

IDBP-71235.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST1H1B

Protein Name

histone cluster 1, H1b

Synonyms

H1; H1.5; H1B; H1F5; H1s-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000330074

InnateDB Gene

IDBG-71233 (HIST1H1B)

Protein Structure

UniProt Annotation

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in the majority of the cell lines tested and in testis. {ECO:0000269PubMed:9031620}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0031490	chromatin DNA binding
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0030307	positive regulation of cell growth
GO:0050821	protein stabilization
GO:0051574	positive regulation of histone H3-K9 methylation
GO:0071169	establishment of protein localization to chromatin