InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGD1

Summary

InnateDB Gene

IDBG-71243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD1

Gene Name

FYVE, RhoGEF and PH domain containing 1

Synonyms

AAS; FGDY; MRXS16; ZFYVE3

Species

Homo sapiens

Ensembl Gene

ENSG00000102302

Encoded Proteins

IDBP-71245

FYVE, RhoGEF and PH domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:54445454-54496166

Strand

Reverse strand

Band

p11.22

Transcripts

ENST00000375135

ENSP00000364277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007275	multicellular organismal development
GO:0008360	regulation of cell shape
GO:0009887	organ morphogenesis
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway