InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgd1

Summary

InnateDB Gene

IDBG-178715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgd1

Gene Name

FYVE, RhoGEF and PH domain containing 1

Synonyms

ZFYVE3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025265

Encoded Proteins

IDBP-178717

FYVE, RhoGEF and PH domain containing 1

IDBP-255488

FYVE, RhoGEF and PH domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:151046150-151089521

Strand

Forward strand

Band

Transcripts

ENSMUST00000026296	ENSMUSP00000026296
ENSMUST00000112685	ENSMUSP00000108305
ENSMUST00000124882
ENSMUST00000125620

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0035023	regulation of Rho protein signal transduction
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly