Version 5.4
Homo sapiens Gene: ORC4
Summary
InnateDB Gene IDBG-71780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC4
Gene Name origin recognition complex, subunit 4
Synonyms ORC4L; ORC4P
Species Homo sapiens
Ensembl Gene ENSG00000115947
Encoded Proteins
IDBP-71782
origin recognition complex, subunit 4
IDBP-244809
origin recognition complex, subunit 4
IDBP-386354
origin recognition complex, subunit 4
IDBP-386356
origin recognition complex, subunit 4
IDBP-386357
origin recognition complex, subunit 4
IDBP-586240
origin recognition complex, subunit 4
IDBP-589052
origin recognition complex, subunit 4
IDBP-597844
origin recognition complex, subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:147930397-148021604
Strand Reverse strand
Band q23.1
Transcripts
ENST00000264169 ENSP00000264169
ENST00000392857 ENSP00000376597
ENST00000416719 ENSP00000413939
ENST00000457954 ENSP00000391484
ENST00000440042 ENSP00000403105
ENST00000488761
ENST00000481488
ENST00000483608
ENST00000478904
ENST00000461711
ENST00000496670
ENST00000490200
ENST00000495601
ENST00000535373 ENSP00000441953
ENST00000540442 ENSP00000438326
ENST00000536575 ENSP00000441502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006810 transport
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026761
View Gene Order
ENSBTAG00000015291
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_567
Assembly of the ORC complex at the origin of replication pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558364
RefSeq NM_001190879 NM_001190881 NM_001190882 NM_002552 NM_181741 NM_181742 XM_006712556
HUGO
OMIM
CCDS CCDS2187 CCDS54404 CCDS54405
HPRD 09118
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca