Version 5.4
| Bos taurus Gene: ORC4 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-642098.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | ORC4 | ||||||||||||||
| Gene Name | Origin recognition complex subunit 4 | ||||||||||||||
| Synonyms | ORC4L | ||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000015291 | ||||||||||||||
| Encoded Proteins |
Origin recognition complex subunit 4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115947:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 2:48282736-48377766 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
E2F-enabled inhibition of pre-replication complex formation pathway
S Phase pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
E2F mediated regulation of DNA replication pathway
Synthesis of DNA pathway
Cell Cycle pathway
Assembly of the ORC complex at the origin of replication pathway
CDC6 association with the ORC:origin complex pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
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| KEGG | |||||||||||||||
| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Activation of ATR in response to replication stress pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Association of licensing factors with the pre-replicative complex pathway
Switching of origins to a post-replicative state pathway
Activation of the pre-replicative complex pathway
CDC6 association with the ORC:origin complex pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
Assembly of the pre-replicative complex pathway
E2F-enabled inhibition of pre-replication complex formation pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Regulation of DNA replication pathway
Cell Cycle Checkpoints pathway
Assembly of the ORC complex at the origin of replication pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
CDT1 association with the CDC6:ORC:origin complex pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
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| KEGG |
Cell cycle pathway
Cell cycle pathway
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| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | Q2YDI2 | ||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 529245 | ||||||||||||||
| UniGene | Bt.13189 | ||||||||||||||
| RefSeq | NM_001046301 XM_005202444 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | BC110211 | ||||||||||||||
| GenPept | AAI10212 | ||||||||||||||
| RNA Seq Atlas | 529245 | ||||||||||||||