InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RFK

Summary

InnateDB Gene

IDBG-71956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFK

Gene Name

riboflavin kinase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000135002

Encoded Proteins

IDBP-71958

riboflavin kinase

IDBP-476296

riboflavin kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:76385517-76394517

Strand

Reverse strand

Band

q21.13

Transcripts

ENST00000376736	ENSP00000365926
ENST00000490113	ENSP00000417215
ENST00000483155
ENST00000476087
ENST00000472900
ENST00000479197

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008531	riboflavin kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006771	riboflavin metabolic process
GO:0006915	apoptotic process
GO:0009231	riboflavin biosynthetic process
GO:0009398	FMN biosynthetic process
GO:0016310	phosphorylation
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0044281	small molecule metabolic process
GO:0072593	reactive oxygen species metabolic process