InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFK

Summary

InnateDB Protein

IDBP-71958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFK

Protein Name

riboflavin kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365926

InnateDB Gene

IDBG-71956 (RFK)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. {ECO:0000269PubMed:19641494}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain, placenta and urinary bladder.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008531	riboflavin kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006771	riboflavin metabolic process
GO:0006915	apoptotic process
GO:0009231	riboflavin biosynthetic process
GO:0009398	FMN biosynthetic process
GO:0016310	phosphorylation
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0044281	small molecule metabolic process
GO:0072593	reactive oxygen species metabolic process